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1.
Coherent Diffraction Microscopy and Its Applications in Nanoscience
and Biology |
The
discovery of X-ray diffraction from crystals by van Laue, William
Bragg, and Lawrence Bragg nearly a century ago opened up a new
era for visualizing the arrangement of atoms in three dimensions.
Indeed, X-ray crystallography has since made revolutionary impacts
in physics, chemistry, materials sciences, biology and medicine,
and a number of Nobel prizes has been awarded to this field.
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Read Research on Coherent Diffraction Microscopy .
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so-surface renderings of the reconstructed image
from a GaN quantum dot nanoparticle, showing (a) the
front view, (b) the back and (c) the
side view. (d) 3D internal structures of the
nanoparticle
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| 2.
Radiation Dose Reduction and Image Enhancement in Medical Imaging
through Equally-Sloped Tomography |
| Since
its introduction in the 1970s, the X-ray computed tomography
scan (commonly referred to as a CT or CAT scan) has become a
revolutionary medical tool in the diagnosis of a large number
of diseases as well as the visualization of critical interventional
procedures. However, a major limitation of CT is the unavoidable
radiation dose imparted to the patient. .
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Read Research on Radiation Dose Reduction.
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Schematic layout of the iterative EST method. The algorithm
iterates back and forth between Fourier and object space.
In each iteration, the calculated slices are updated with
the measured(experimental) slices in Fourier space and
the physical constraints are enforced in object space.
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| 3.
High-Speed Bio-imaging Project |
Life
is four dimensional. Techniques used to study the molecules making
up life have developed rapidly over the years. While single molecule
techniques can be routinely applied to tracking molecular motions
at the 1 nm level, the temporal resolution is currently limited
to the millisecond or sub-millisecond level, mainly due to the
lack of ultra high-speed cameras.
Read Research on High-Speed Bio-imaging . . .
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Tracking of a 40 nm gold colloid (black circle on cell) non-covalently
linked to TfR1 on the cell surface using DIC illumination with
a frame rate of 40 kHz (i.e. 25 μs temporal resolution).
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