Fall 2008 |
Syllabus |
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| Instructor: |
Giovanni Zocchi |
| Office: |
3-124 Knudsen; |
| Phone: |
(310) 825-4018; |
| Lab: |
PAB A-425, A-429; |
| Phone: |
206 0715 |
| E-mail: |
zocchi@physics.ucla.edu |
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Office hours: by appointment.
Time and location of the class: Tues. & Thu. 12:30-2:00 in Knudsen 6-107.
Textbook: K. Sneppen and G. Zocchi: Physics in Molecular Biology (Cambridge 2005).
Grading: based on the presentation of a paper in the literature. |
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Approximate lecture schedule |
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| Week 1 |
Molecular interactions. Osmotic pressure; depletion forces; electrostatics in water; hydrophobic interaction; hydrogen bonds; Van der Waals forces.
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| 2 |
Polymer Physics (chapter 2).
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3-4 |
DNA (chapter 3). DNA structure; recombinant DNA technology; phase transitions in DNA (DNA melting): models & experiments.
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| 5 |
Protein structure and protein folding (chapters 4, 5).
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| 6-7 |
Conformational transitions in proteins. Allosteric networks;
nanotechnology approach to artificial allostery.
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| 8-9 |
Genetic regulation: the λ-phage in E. coli (chapter 7)
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| 10 |
Models of evolution (chapter 9).
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1_Molecular Interactions_A
2_Osmotic pressure & depletion forces.
3_Electrostatics in water.
4_Molecular Interactions_B.
5_Polymers.
6_DNA structure.
7_Protein structure.
9_Genetic regulation.
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