- Alyson Ashe et al.
- Cell, Volume 150, Issue 1, 6 July 2012, Pages 88–993
- Transgenerational effects have wide-ranging implications for human health, biological adaptation, and evolution; however, their mechanisms and biology remain poorly understood.
- Here, they demonstrate that a germline nuclear small RNA/chromatin pathway can maintain stable inheritance for many generations when triggered by a piRNA-dependent foreign RNA response in C. elegans.
- Using forward genetic screens and candidate approaches, they find that a core set of nuclear RNAi and chromatin factors is required for multigenerational inheritance of environmental RNAi and piRNA silencing.
